D-Mannitol

Storage: Keep container tightly closed in a dry and well-ventilated place

Safety: Not classified as hazardous; keep away from moisture and heat

CAS Number: 69-65-8

EC Number: 200-711-8

Molecular Formula: C6H14O6

Molecular Weight: 182.17 g/mol

Appearance: White crystalline powder

Solubility: 213 g/l (25ºC)

pH: 5-7 (100 g/l, H2O, 20ºC)

Melting Point: 164-169ºC

Boiling Point: 290-295ºC

Bulk Density: 400-500 Kg/m³

D-mannitol is a naturally occurring sugar alcohol widely used in both pharmaceutical and food industries due to its unique properties. In the pharmaceutical sector, D-mannitol serves as a critical excipient in the formulation of injectables, tablets, and lyophilized products. It is valued for its ability to stabilize proteins and enzymes, acting as a cryoprotectant during freeze-drying processes. Additionally, D-mannitol is employed as an osmotic diuretic to reduce intracranial pressure and intraocular pressure, and is used in diagnostic procedures such as glomerular filtration rate (GFR) tests. Its low hygroscopicity and high solubility make it an ideal bulking agent and diluent in various drug delivery systems.​

In the food industry, D-mannitol is recognized for its sweet taste, low calorie content, and non-cariogenic properties, making it a suitable sugar substitute for diabetic-friendly and low-calorie products. It is used as a texturizer, humectant, and anti-caking agent in confectionery, chewing gum, and baked goods. D-mannitol also finds application in oral care products due to its cooling effect and pleasant taste. Its GRAS (Generally Recognized As Safe) status and compatibility with a wide range of food matrices make it a versatile ingredient for manufacturers seeking functional and safe alternatives to traditional sugars.​

This dual functionality—pharmaceutical stabilization and food formulation—makes D-mannitol a valuable ingredient across diverse product categories, supporting both health and sensory benefits in consumer goods